After all, it has been revealed that George W. Bush underwent a stent procedure in order to open a blocked artery. That kind of news is certain to bring out the hate from the port side of cyberspace.
This blog, of course, is a well-mannered and civilized place, so its hard-working staff wishes President Bush a speedy and complete recovery, and a long and happy life.
I am old enough to remember the days when contracting HIV meant a death sentence; the only question was how long the afflicted had to live. Thankfully, things are different now:
Two H.I.V.-infected patients in Boston who had bone-marrow transplants for blood cancers have apparently been virus-free for weeks since their antiretroviral drugs were stopped, researchers at an international AIDS conference announced Wednesday.No, a cure is not right around the corner. But as the story indicates, we are learning more every day about how to fight HIV/AIDS, and the prospect of a cure is not nearly the fantasy that it used to be.
The patients’ success echoes that of Timothy Ray Brown, the famous “Berlin patient,” who has shown no signs of resurgent virus in the five years since he got a bone-marrow transplant from a donor with a rare mutation conferring resistance to H.I.V.
The Boston cases, like Mr. Brown’s, are of no practical use to the 34 million people in the world who have H.I.V. but neither blood cancer nor access to premier cancer-treatment hospitals.
But AIDS experts still find the Boston cases exciting because they are another step in the long and so-far-fruitless search for a cure. They offer encouragement to ambitious future projects to genetically re-engineer infected patients’ cells to be infection-resistant. At least two teams are already experimenting with variants on this idea, said Dr. Steven G. Deeks, an AIDS researcher at the University of California, San Francisco.
Dr. Françoise Barré-Sinoussi, a discoverer of the virus that causes AIDS and the president of the International AIDS Society, called the findings about the Boston patients “very interesting and very encouraging.” The announcement about the cases was made at the society’s annual conference in Kuala Lumpur, Malaysia.
Fiorina and his team studied hundreds of pathways in animals with diabetes. They eventually isolated one, known as ATP/P2X7R, which triggers the T-cell attacks on the pancreas, rendering it unable to produce insulin.
“By identifying the ATP/P2X7R pathway as the early mechanism in the body that fires up an alloimmune response, we found the root cause of diabetes,” says Fiorina. “With the cause identified, we can now focus on treatment options. Everything from drug therapies to transplants that require less immunosuppression is being explored.”
This has extraordinary implications for people under 20 who have type 1 or type 2 diabetes. According to the article, it will still be a few years before therapies can be tested, but now, we are very close to finally having a cure for a large subset of the population living with diabetes.
Want to live forever? Drink coffee:
For hundreds of years, coffee has been one of the two or three most popular beverages on earth. But it’s only recently that scientists are figuring out that the drink has notable health benefits. In one large-scale epidemiological study from last year, researchers primarily at the National Cancer Institute parsed health information from more than 400,000 volunteers, ages 50 to 71, who were free of major diseases at the study’s start in 1995. By 2008, more than 50,000 of the participants had died. But men who reported drinking two or three cups of coffee a day were 10 percent less likely to have died than those who didn’t drink coffee, while women drinking the same amount had 13 percent less risk of dying during the study. It’s not clear exactly what coffee had to do with their longevity, but the correlation is striking.
Other recent studies have linked moderate coffee drinking — the equivalent of three or four 5-ounce cups of coffee a day or a single venti-size Starbucks — with more specific advantages: a reduction in the risk of developing Type 2 diabetes, basal cell carcinoma (the most common skin cancer), prostate cancer, oral cancer and breast cancer recurrence.
Perhaps most consequential, animal experiments show that caffeine may reshape the biochemical environment inside our brains in ways that could stave off dementia. In a 2012 experiment at the University of Illinois at Urbana-Champaign, mice were briefly starved of oxygen, causing them to lose the ability to form memories. Half of the mice received a dose of caffeine that was the equivalent of several cups of coffee. After they were reoxygenated, the caffeinated mice regained their ability to form new memories 33 percent faster than the uncaffeinated. Close examination of the animals’ brain tissue showed that the caffeine disrupted the action of adenosine, a substance inside cells that usually provides energy, but can become destructive if it leaks out when the cells are injured or under stress. The escaped adenosine can jump-start a biochemical cascade leading to inflammation, which can disrupt the function of neurons, and potentially contribute to neurodegeneration or, in other words, dementia.
Read the whole thing. I am guessing that this means tea also does a body good.
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